Annual high-dose vitamin D3 and mental well-being: Randomised controlled trial

KM Sanders; AL Stuart; EJ Williamson; FN Jacka; S Dodd; G Nicholson; M Berk

Journal article

Annual high-dose vitamin D3 and mental well-being: Randomised controlled trial

KM Sanders, AL Stuart, EJ Williamson, FN Jacka, S Dodd, G Nicholson, M Berk

British Journal of Psychiatry | Published : 2011

DOI: 10.1192/bjp.bp.110.087544

Abstract

Background: Epidemiological evidence supports a relationship between vitamin D and mental well-being, although evidence from large-scale placebo-controlled intervention trials is lacking. Aims: To examine if vitamin D supplementation has a beneficial effect on mood in community-dwelling older women; if a single annual large dose of vitamin D has a role in the prevention of depressive symptoms; and if there is an association between serum 25-hydroxyvitamin D levels and mental health. Method: A double-blind, randomised, placebo-controlled trial of women aged 70 or older (the Vital D Study: ISRCTN83409867 and ACTR12605000658617). Participants were randomly assigned to receive 500000IU vitamin D..

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University of Melbourne Researchers

Kerrie Sanders Author

Michael Berk Author

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)

Awarded by NHMRC

Funding Acknowledgements

This study was funded through a 1-year project grant from the Australian National Health and Medical Research Council (NHMRC No. 509109). Initially, the vital D study was funded through a 5-year NHMRC project grant (NHMRC No. 251682), with additional funding aimed specifically at recruitment granted through the Government Department of Health and Ageing.